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  1. Chapter 007. Medical Disorders during Pregnancy

    Harrison's Internal Medicine > Part 1. Introduction to Clinical Medicine > Chapter 7. Medical Disorders during Pregnancy
    Medical Disorders during Pregnancy: Introduction
    Approximately 4 million births occur in the United States each year. A significant proportion of these are complicated by one or more medical disorders. Three decades ago, many medical disorders were contraindications to pregnancy. Advances in obstetrics, neonatology, obstetric anesthesiology, and medicine have ...
  2. Chapter 006. Women's Health

    Harrison's Internal Medicine > Chapter 6. Women's Health
    Women's Health: Introduction
    The study of biologic differences between sexes has emerged as a distinct scientific discipline. A report from the Institute of Medicine (IOM) found that sex has a broad impact on biologic and disease processes and succinctly concluded: sex matters. The National Institutes of Health established the Office of Research on Women's Health in 1990 to develop an agenda for future research in the field. ...
  3. Chapter 005. Principles of Clinical Pharmacology

    Harrison's Internal Medicine > Chapter 5. Principles of Clinical Pharmacology
    Principles of Clinical Pharmacology: Introduction
    Drugs are the cornerstone of modern therapeutics. Nevertheless, it is well recognized among physicians and among the lay community that the outcome of drug therapy varies widely among individuals. While this variability has been perceived as an unpredictable, and therefore inevitable, accompaniment of drug therapy, this is not the case. The goal of this chapter ...
  4. Chapter 004. Screening and Prevention of Disease

    Harrison's Internal Medicine > Chapter 4. Screening and Prevention of Disease
    Screening and Prevention of Disease: Introduction
    A primary goal of health care is to prevent disease or to detect it early enough that intervention will be more effective. Strategies for disease screening and prevention are driven by evidence that testing and intervention are practical and effective. Currently most screening tests are readily available and inexpensive. Examples include tests that are biochemical ...
  5. Chapter 003. Decision-Making in Clinical Medicine

    Harrison's Internal Medicine > Chapter 3. Decision-Making in Clinical Medicine
    Decision-Making in Clinical Medicine: Introduction
    To the medical student who requires 2 h to collect a patient's history and perform a physical examination, and several additional hours to organize them into a coherent presentation, the experienced clinician's ability to reach a diagnosis and decide on a management plan in a fraction of the time seems extraordinary. While medical knowledge and experience ...
  6. Chapter 002. Global Issues in Medicine

    Harrison's Internal Medicine > Chapter 2. Global Issues in Medicine
    Why Global Health?
    Global health, it has been noted, is not a discipline; it is, rather, a collection of problems. No single review can do much more than lay out the leading problems faced in applying evidence-based medicine in settings of great poverty or across national boundaries. In this chapter, we first introduce the major international bodies engaged in addressing these problems; identify the more significant ...
  7. Chapter 001. The Practice of Medicine

  8. Chapter 200. Pneumocystis Infection

    Harrison's Internal Medicine > Chapter 200. Pneumocystis Infection
    Definition and Description
    Pneumocystis is an opportunistic fungal pulmonary pathogen that is an important cause of pneumonia in the immunocompromised host. Although organisms within the Pneumocystis genus are morphologically very similar, they are genetically diverse and host-specific. P. jirovecii infects humans, whereas P. carinii—the original species described in 1909—infects rats. For clarity, only the genus ...
  9. Chapter 199. Miscellaneous Mycoses and Algal Infections

    Harrison's Internal Medicine > Chapter 199. Miscellaneous Mycoses and Algal Infections
    Mycoses
    The clinical spectrum of fungal disease varies from superficial infections of the skin, hair, and nails to life-threatening systemic infections. Superficial infections involve the outermost layers of skin and hair and are associated with little or no inflammation. Cutaneous infections involve deeper layers of the skin, hair follicles, and nails and are accompanied by inflammation. Subcutaneous ...
  10. Chapter 198. Mucormycosis

    Harrison's Internal Medicine > Chapter 198. Mucormycosis
    Mucormycosis: Introduction
    Mucormycosis (also called zygomycosis) is a serious, relatively uncommon invasive fungal infection and one of the most aggressive and lethal invasive mycoses. Physicians caring for patients with diabetes mellitus, immunocompromise (including that following organ transplantation), or iron overload syndromes (particularly those associated with hemodialysis) should be acutely aware of the enhanced susceptibility ...
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